What is Alpha Derma CE?

Alpha Derma CE is touted as another Botox alternative cream. The manufacture claims that it helps reduce wrinkles by relaxing the underlying muscle.

Once the muscle is relaxed the wrinkles (such as crows feet and worry lines between the eyebrows and on the forehead) flatten out. 

The cream was developed by Janson Beckett and was pretty popular in the early 2000s.

Some claim that it's differs from all the other “typical” botox creams on the market because it has more clinically proven ingredient – including peptides – which other don’t have.

Here is a rundown of the (8) eight active ingredients and their function.

10% Argireline

  • Argireline blocks the nerve signals that control the contraction of facial muscles. This produces a significant reduction in both the depth and size of fine lines and folds.


  • An amino acid that helps to lessen and relax muscle contraction. Impairing muscle contraction is what makes the skin look younger.


  • Another natural amino acid that helps prevents neurons from transmitting signals that cause muscles to contract. When repetitive movements are slowed, the formation of fine lines are prevented.

Alpha Lipoic Acid

  • Alpha Lipoic Acid is an advanced antioxidant that helps fight free radicals - one of the major causes of aging. Some researchers claim it is an antioxidant 400 times more potent than Vitamin C & E. Beyond anti-free radical action, it repairs aged dermis, contributing to a healthy looking, glowing complexion.

Vitamin C Ester

  • Vitamin C Ester (ascorbyl palmitate) boosts protective antioxidant action and helps repair past damage by aiding new collagen production.


  • Dimethylaminoethanol (DMAE), often called “facelift in a jar” by some skin specialists, helps firm and tighten. With regular use DMAE will give skin a more defined, youthful appearance.

Other ingredients include: collagen,elastin, soy, and UV-A and UV-B [SPF15].


I've used this product for about 3 weeks and had to stop due because I developed a dry, scaly rash around my eyes.

I guess I didn't give it enough time to see if it did reduce my wrinkles - but obviously my skin couldn't handle it.

I don't believe any cream can actually work like a Botox injection and paralyze the underlying muscle.

If it did, it would be consider a drug and therefore would never be sold as an over-the-counter cosmetic.

Benefits of Peptides

However, if you are looking to benefit from the skin pluming effects of  peptides - you can find out about that here....

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